Molecular design of novel spin-labeled nucleosides directly attached base moiety
نویسندگان
چکیده
منابع مشابه
Novel Spin Labeled Azacrown Ethers
The ability of crown ethers [1—4] and cryptands [5—7] to selectively complex ions and neutral molecules has been the subject of extensive studies over the past two decades. One of the most impor tant problems under investigation was the transport of ionic species through membranes in biological sys tems [8 ]. Of several transport mechanisms proposed and demonstrated in natural and artificial ...
متن کاملBase-Modified Nucleosides: Etheno Derivatives
This review presents synthesis and chemistry of nucleoside analogs, possessing an additional fused, heterocyclic ring of the "etheno" type, such as 1,N(6)-ethenoadenosine, 1,N(4)-ethenocytidine, 1,N(2)-ethenoguanosine, and other related derivatives. Formation of ethenonucleosides, in the presence of α-halocarbonyl reagents and their mechanism, stability, and degradation, reactions of substituti...
متن کاملDesign, Molecular Docking Studies and Toxicity Prediction of Some Novel 1, 2, 3-Triazole Derivatives Containing Piperazine Moiety as Antifungal Agents and CYP-51 Inhibitors
Background & Objective: In this study, a number of new triazole derivatives, containing a 1, 2, 3-triazole ring attached to the piperazine moiety as antifungal agents and lanosterol 14 alpha-demethylase, (CYP51) inhibitors were docking studies conducted. In the following, the toxicity risks of the designed compounds, were predicted by existing software. Materials & methods: Initially, the chemi...
متن کاملInvestigation of Nucleosides Molecular Structure
The investigations of nucleoside molecular structures are of fundamental interest for molecular biology. Up to the present the main experimental information about their structure was obtained from the data for the crystals and solutions [1]. But the intermolecular interaction strongly influences on the conformational and tautomeric equilibrium. And their result can not be compared with quantum ...
متن کاملMultifrequency electron spin resonance spectra of a spin-labeled protein calculated from molecular dynamics simulations.
Multifrequency electron spin resonance (ESR) spectra provide a wealth of structural and dynamic information about the local environment of the spin label and, indirectly, about the spin-labeled protein. Relating the features of the observed spectra to the underlying molecular motions and interactions is, however, challenging. To make progress toward a rigorous interpretation of ESR spectra, we ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Symposium Series
سال: 2004
ISSN: 0261-3166
DOI: 10.1093/nass/48.1.5